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- X-linked: X-linked refers to any condition in which the gene that has a mutation is found on the X chromosome. In X-linked inheritance, the sex of the person who is affected matters in terms of the risk to the children of that person’s chance of having inherited the condition. Females have two X chromosomes, and males have an X and a Y chromosome. Females have a 50% risk of passing on the condition to her children in each pregnancy. Males will pass on their X chromosome to all of his daughters, and thus all his daughters will inherit the mutation. Males will pass on their Y chromosome to all of his sons, and thus all his sons will not inherit the mutation and will not have CMT.
